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Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design
IMPORTANCE: The heterogeneity of rate of clinical progression among patients with Alzheimer disease leads to difficulty in providing clinical counseling and diminishes the power of clinical trials using disease-modifying agents. OBJECTIVE: To gain a better understanding of the factors that affect th...
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| Vydáno v: | JAMA Neurol |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5547572/ https://ncbi.nlm.nih.gov/pubmed/28288263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2016.5953 |
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