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Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer
As tumor PD-L1 provides signals to anti-tumor PD-1(+) T cells that blunt their functions, αPD-1 and αPD-L1 antibodies have been developed as anti-cancer immunotherapies based on interrupting this signaling axis. However, tumor cell-intrinsic PD-L1 signals also regulate immune-independent tumor cell...
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| 出版年: | Signal Transduct Target Ther |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5547561/ https://ncbi.nlm.nih.gov/pubmed/28798885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sigtrans.2016.30 |
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