CD122-selective IL-2 complexes reduce immunosuppression, promote Treg fragility, and sensitize tumor response to PD-L1 blockade

The IL-2 receptor (IL-2R) is an attractive cancer immunotherapy target that controls immunosuppressive T regulatory cells (Tregs) and anti-tumor T cells. Here we used IL-2Rβ-selective IL-2/anti-IL-2 complexes (IL-2c) to stimulate effector T cells preferentially in the orthotopic mouse ID8agg ovarian...

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Publicat a:Cancer Res
Autors principals: Drerup, Justin M., Deng, Yilun, Pandeswara, Sri Lakshmi, Padrón, Álvaro S., Reyes, Ryan M., Zhang, Xinyue, Mendez, Jenny, Liu, Aijie, Clark, Curtis A., Chen, Wanjiao, Conejo-Garcia, José R., Hurez, Vincent, Gupta, Harshita, Curiel, Tyler J.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669742/
https://ncbi.nlm.nih.gov/pubmed/32948605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0002
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