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Immune stimulatory effects of rapamycin are mediated by stimulation of antitumor γδ T cells
The FDA approved mTOR inhibitor rapamycin mediates important immune effects, but their contributions to the drug's anti-cancer effects are unclear. Here we report evidence that rapamycin-mediated cancer protection relies upon stimulation of γδ T cells. In a well-established mouse model of carci...
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| Veröffentlicht in: | Cancer Res |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5065775/ https://ncbi.nlm.nih.gov/pubmed/27569211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0091 |
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