Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice

The mammalian (mechanistic) target of rapamycin (mTOR) regulates critical immune processes that remain incompletely defined. Interest in mTOR inhibitor drugs is heightened by recent demonstrations that the mTOR inhibitor rapamycin extends lifespan and healthspan in mice. Rapamycin or related analogu...

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Dettagli Bibliografici
Pubblicato in:Aging Cell
Autori principali: Hurez, Vincent, Dao, Vinh, Liu, Aijie, Pandeswara, Srilakshmi, Gelfond, Jonathan, Sun, Lishi, Bergman, Molly, Orihuela, Carlos J., Galvan, Veronica, Padrón, Álvaro, Drerup, Justin, Liu, Yang, Hasty, Paul, Sharp, Zelton Dave, Curiel, Tyler J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693453/
https://ncbi.nlm.nih.gov/pubmed/26315673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12380
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