Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune‐deficient mice

The mammalian (mechanistic) target of rapamycin (mTOR) regulates critical immune processes that remain incompletely defined. Interest in mTOR inhibitor drugs is heightened by recent demonstrations that the mTOR inhibitor rapamycin extends lifespan and healthspan in mice. Rapamycin or related analogu...

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Bibliografiske detaljer
Udgivet i:Aging Cell
Main Authors: Hurez, Vincent, Dao, Vinh, Liu, Aijie, Pandeswara, Srilakshmi, Gelfond, Jonathan, Sun, Lishi, Bergman, Molly, Orihuela, Carlos J., Galvan, Veronica, Padrón, Álvaro, Drerup, Justin, Liu, Yang, Hasty, Paul, Sharp, Zelton Dave, Curiel, Tyler J.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4693453/
https://ncbi.nlm.nih.gov/pubmed/26315673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12380
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