Rapamycin prevents surgery-induced immune dysfunction in patients with bladder cancer

The mechanistic target of rapamycin (mTOR) integrates environmental inputs to regulate cellular growth and metabolism in tumors. However, mTOR also regulates T-cell differentiation and activation, rendering applications of mTOR inhibitors towards treating cancer complex. Preclinical data supports di...

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Publicat a:Cancer Immunol Res
Autors principals: Svatek, Robert S., Ji, Niannian, de Leon, Essel, Mukherjee, Neelam, Kabra, Aashish, Hurez, Vincent, Nicolas, Marlo, Michalek, Joel E., Javors, Martin, Wheeler, Karen, Sharp, Z. Dave, Livi, Carolina B., Shu, Zhen-Ju, Henkes, David, Curiel, Tyler J.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926429/
https://ncbi.nlm.nih.gov/pubmed/30563829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-18-0336
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