Bladder cancer cell‐intrinsic PD‐L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy

Tumor cell‐intrinsic programmed death‐ligand 1 (PD‐L1) signals mediate immunopathologic effects in breast, colon, and ovarian cancers and in melanomas, but bladder cancer (BC) effects are unreported. We show here that BC cell‐intrinsic PD‐L1 signals in mouse MB49 and human RT4, UM‐UC3, and UM‐UC‐14...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancer Med
Päätekijät: Zhang, Deyi, Reyes, Ryan M., Osta, Erica, Kari, Suresh, Gupta, Harshita B., Padron, Alvaro S., Kornepati, Anand V. R., Kancharla, Aravind, Sun, Xiujie, Deng, Yilun, Wu, Bogang, Vadlamudi, Ratna, Li, Rong, Svatek, Robert S., Curiel, Tyler J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2021
Aiheet:
Cancer Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7957205/
https://ncbi.nlm.nih.gov/pubmed/33626233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3739
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