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Progressive Neuronal Activation Accompanies Epileptogenesis Caused by Hippocampal Glutamine Synthetase Inhibition

Loss of glutamine synthetase (GS) in hippocampal astrocytes has been implicated in the causation of human mesial temporal lobe epilepsy (MTLE). However, the mechanism by which the deficiency in GS leads to epilepsy is incompletely understood. Here we ask how hippocampal GS inhibition affects seizure...

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Detalles Bibliográficos
Publicado en:Exp Neurol
Main Authors: Albright, Benjamin, Dhaher, Roni, Wang, Helen, Harb, Roa, Lee, Tih-Shih W., Zaveri, Hitten, Eid, Tore
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547560/
https://ncbi.nlm.nih.gov/pubmed/27769717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2016.10.007
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