2235 15N-Leucine transport across the blood brain barrier is significantly impaired in the glutamine synthetase-inhibited brain

OBJECTIVES/SPECIFIC AIMS: Astroglial glutamine synthetase (GS), which metabolizes glutamate and ammonia to glutamine, is critical for the detoxification of brain ammonia, clearance of synaptic glutamate, and production of brain glutamine. Perturbations in the expression and activity of GS are though...

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Bibliografiska uppgifter
I publikationen:J Clin Transl Sci
Huvudupphovsmän: Gruenbaum, Shaun E., Dhaher, Roni, Behar, Kevin, Zaveri, Hitten, Erfe, Mark, Eid, Tore
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cambridge University Press 2018
Ämnen:
Basic/Translational Science/Team Science
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6808188/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2018.37
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