Progressive Neuronal Activation Accompanies Epileptogenesis Caused by Hippocampal Glutamine Synthetase Inhibition

Loss of glutamine synthetase (GS) in hippocampal astrocytes has been implicated in the causation of human mesial temporal lobe epilepsy (MTLE). However, the mechanism by which the deficiency in GS leads to epilepsy is incompletely understood. Here we ask how hippocampal GS inhibition affects seizure...

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Udgivet i:Exp Neurol
Main Authors: Albright, Benjamin, Dhaher, Roni, Wang, Helen, Harb, Roa, Lee, Tih-Shih W., Zaveri, Hitten, Eid, Tore
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547560/
https://ncbi.nlm.nih.gov/pubmed/27769717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2016.10.007
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