Intracellular trafficking of new anticancer therapeutics: antibody–drug conjugates

Antibody–drug conjugate (ADC) is a milestone in targeted cancer therapy that comprises of monoclonal antibodies chemically linked to cytotoxic drugs. Internalization of ADC takes place via clathrin-mediated endocytosis, caveolae-mediated endocytosis, and pinocytosis. Conjugation strategies, endocyto...

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Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Kalim, Muhammad, Chen, Jie, Wang, Shenghao, Lin, Caiyao, Ullah, Saif, Liang, Keying, Ding, Qian, Chen, Shuqing, Zhan, Jinbiao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2017
Soggetti:
Review
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546728/
https://ncbi.nlm.nih.gov/pubmed/28814834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S135571
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