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Implications of receptor-mediated endocytosis and intracellular trafficking dynamics in the development of antibody drug conjugates
The use of antibody-drug conjugates (ADCs) as a therapeutic platform to treat cancer has recently gained substantial momentum. This therapeutic modality has the potential to increase the efficacy and reduce the systemic toxicity associated with current therapeutic regimens. The efficacy of ADCs, how...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Landes Bioscience
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3564878/ https://ncbi.nlm.nih.gov/pubmed/23221464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.22854 |
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