Antibody-mediated endocytosis of polysialic acid enables intracellular delivery and cytotoxicity of a glycan-directed antibody-drug conjugate

The specific targeting of differentially expressed glycans in malignant cells has emerged as an attractive anti-cancer strategy. One such target is the oncodevelopmental antigen polysialic acid (polySia), a polymer of α2,8-linked sialic acid residues that is largely absent during postnatal developme...

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Udgivet i:Cancer Res
Main Authors: Cox, Emily C., Thornlow, Dana N., Jones, Michaela A., Fuller, Jordan L., Merritt, Judith H., Paszek, Matthew J., Alabi, Christopher A., DeLisa, Matthew P.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467748/
https://ncbi.nlm.nih.gov/pubmed/30808675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3119
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