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Efficient development and expression of scFv recombinant proteins against PD-L1 surface domain and potency in cancer therapy
PD-L1 is a 40 kDa trans-membrane protein of B7 family and an important T cell regulator. Binding of PD-L1 and PD-1 inhibits proliferation and activation of T cell results cell exhaustion. This phenomenon can be reversed by blocking PD-L1/PD-1 interactions with single chain variables fragment (scFv)...
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| Veröffentlicht in: | Cytotechnology |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer Netherlands
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6546791/ https://ncbi.nlm.nih.gov/pubmed/31098772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-019-00316-3 |
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