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Lack of β, β-carotene -9’, 10’-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice

SCOPE: β,β-carotene-9’,10’-dioxygenase 2 (BCO2) is a carotenoid cleavage enzyme localized to the inner mitochondrial membrane in mammals. This study was aimed to assess the impact of genetic ablation of BCO2 on hepatic oxidative stress through mitochondrial function in mice. METHODS AND RESULTS: Liv...

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Detalhes bibliográficos
Publicado no:Mol Nutr Food Res
Main Authors: Wu, Lei, Guo, Xin, Hartson, Steven D., Davis, Mary Abby, He, Hui, Medeiros, Denis M., Wang, Weiqun, Clarke, Stephen L., Lucas, Edralin, Smith, Brenda J., von Lintig, Johannes, Lin, Dingbo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546151/
https://ncbi.nlm.nih.gov/pubmed/27991717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201600576
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