β-carotene oxygenase 2 deficiency-triggered mitochondrial oxidative stress promotes low-grade inflammation and metabolic dysfunction

Low-grade inflammation is a critical pathological factor contributing to the development of metabolic disorders. β-carotene oxygenase 2 (BCO2) was initially identified as an enzyme catalyzing carotenoids in the inner mitochondrial membrane. Mutations in BCO2 are associated with inflammation and meta...

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Vydáno v:Free Radic Biol Med
Hlavní autoři: Wu, Lei, Lu, Peiran, Guo, Xin, Song, Kun, Lyu, Yi, Bothwell, James, Wu, Jinglong, Hawkins, Olivia, Clarke, Stephen L., Lucas, Edralin A., Smith, Brenda J., Chowanadisai, Winyoo, Hartson, Steve D, Ritchey, Jerry W., Wang, Weiqun, Medeiros, Denis M., Li, Shitao, Lin, Dingbo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7946548/
https://ncbi.nlm.nih.gov/pubmed/33453359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2021.01.003
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