Lack of β, β-carotene -9’, 10’-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice

SCOPE: β,β-carotene-9’,10’-dioxygenase 2 (BCO2) is a carotenoid cleavage enzyme localized to the inner mitochondrial membrane in mammals. This study was aimed to assess the impact of genetic ablation of BCO2 on hepatic oxidative stress through mitochondrial function in mice. METHODS AND RESULTS: Liv...

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Vydáno v:Mol Nutr Food Res
Hlavní autoři: Wu, Lei, Guo, Xin, Hartson, Steven D., Davis, Mary Abby, He, Hui, Medeiros, Denis M., Wang, Weiqun, Clarke, Stephen L., Lucas, Edralin, Smith, Brenda J., von Lintig, Johannes, Lin, Dingbo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546151/
https://ncbi.nlm.nih.gov/pubmed/27991717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201600576
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