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The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects
H-Ras, K-Ras, and N-Ras are small GTPases that are important in the control of cell proliferation, differentiation, and survival, and their mutants occur frequently in human cancers. The G-domain, which catalyzes GTP hydrolysis and mediates downstream signaling, is 95% conserved between the Ras isof...
Enregistré dans:
| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5546037/ https://ncbi.nlm.nih.gov/pubmed/28630043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.778886 |
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