An engineered protein antagonist of K-Ras/B-Raf interaction

Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to standard therapies. Here we report the engineering of a protein scaffold for preferent...

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Publicado no:Sci Rep
Main Authors: Kauke, Monique J., Traxlmayr, Michael W., Parker, Jillian A., Kiefer, Jonathan D., Knihtila, Ryan, McGee, John, Verdine, Greg, Mattos, Carla, Wittrup, K. Dane
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517481/
https://ncbi.nlm.nih.gov/pubmed/28724936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05889-7
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