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An engineered protein antagonist of K-Ras/B-Raf interaction
Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to standard therapies. Here we report the engineering of a protein scaffold for preferent...
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| Опубликовано в: : | Sci Rep |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5517481/ https://ncbi.nlm.nih.gov/pubmed/28724936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05889-7 |
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