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Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate

RAS GTPase is a prototype for nucleotide-binding proteins that function by cycling between GTP and GDP, with hydrogen atoms playing an important role in the GTP hydrolysis mechanism. It is one of the most well studied proteins in the superfamily of small GTPases, which has representatives in a wide...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Knihtila, Ryan, Holzapfel, Genevieve, Weiss, Kevin, Meilleur, Flora, Mattos, Carla
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692228/
https://ncbi.nlm.nih.gov/pubmed/26515069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679860
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