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Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate

RAS GTPase is a prototype for nucleotide-binding proteins that function by cycling between GTP and GDP, with hydrogen atoms playing an important role in the GTP hydrolysis mechanism. It is one of the most well studied proteins in the superfamily of small GTPases, which has representatives in a wide...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Knihtila, Ryan, Holzapfel, Genevieve, Weiss, Kevin, Meilleur, Flora, Mattos, Carla
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692228/
https://ncbi.nlm.nih.gov/pubmed/26515069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679860
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