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Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate

RAS GTPase is a prototype for nucleotide-binding proteins that function by cycling between GTP and GDP, with hydrogen atoms playing an important role in the GTP hydrolysis mechanism. It is one of the most well studied proteins in the superfamily of small GTPases, which has representatives in a wide...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Knihtila, Ryan, Holzapfel, Genevieve, Weiss, Kevin, Meilleur, Flora, Mattos, Carla
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4692228/
https://ncbi.nlm.nih.gov/pubmed/26515069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679860
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