Endogenous glucocorticoid deficiency in psoriasis promotes inflammation and abnormal differentiation

The factors involved in maintaining a localized inflammatory state in psoriatic skin remain poorly understood. Here, we demonstrate through metabolomic and transcriptomic profiling marked suppression of glucocorticoid biosynthesis in the epidermis of psoriatic skin leading to localized deficiency of...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Main Authors: Sarkar, Mrinal K., Kaplan, Nihal, Tsoi, Lam C, Xing, Xianying, Liang, Yun, Swindell, William R., Hoover, Paul, Aravind, Maya, Baida, Gleb, Clark, Matthew, Voorhees, John J, Nair, Rajan P, Elder, James T., Budinova, Irina, Getsios, Spiro, Gudjonsson, Johann E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545780/
https://ncbi.nlm.nih.gov/pubmed/28259685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2017.02.972
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