Endogenous glucocorticoid deficiency in psoriasis promotes inflammation and abnormal differentiation

The factors involved in maintaining a localized inflammatory state in psoriatic skin remain poorly understood. Here, we demonstrate through metabolomic and transcriptomic profiling marked suppression of glucocorticoid biosynthesis in the epidermis of psoriatic skin leading to localized deficiency of...

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Pubblicato in:J Invest Dermatol
Autori principali: Sarkar, Mrinal K., Kaplan, Nihal, Tsoi, Lam C, Xing, Xianying, Liang, Yun, Swindell, William R., Hoover, Paul, Aravind, Maya, Baida, Gleb, Clark, Matthew, Voorhees, John J, Nair, Rajan P, Elder, James T., Budinova, Irina, Getsios, Spiro, Gudjonsson, Johann E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545780/
https://ncbi.nlm.nih.gov/pubmed/28259685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2017.02.972
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