Endogenous glucocorticoid deficiency in psoriasis promotes inflammation and abnormal differentiation

The factors involved in maintaining a localized inflammatory state in psoriatic skin remain poorly understood. Here, we demonstrate through metabolomic and transcriptomic profiling marked suppression of glucocorticoid biosynthesis in the epidermis of psoriatic skin leading to localized deficiency of...

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Bibliografiske detaljer
Udgivet i:J Invest Dermatol
Main Authors: Sarkar, Mrinal K., Kaplan, Nihal, Tsoi, Lam C, Xing, Xianying, Liang, Yun, Swindell, William R., Hoover, Paul, Aravind, Maya, Baida, Gleb, Clark, Matthew, Voorhees, John J, Nair, Rajan P, Elder, James T., Budinova, Irina, Getsios, Spiro, Gudjonsson, Johann E.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545780/
https://ncbi.nlm.nih.gov/pubmed/28259685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2017.02.972
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