Analyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells

Specific functions for different cyclic nucleotide phosphodiesterases (PDEs) have not yet been identified in most cell types. Conventional approaches to study PDE function typically rely on measurements of global cAMP, general increases in cAMP-dependent protein kinase (PKA), or the activity of exch...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Beltejar, Michael-Claude G., Lau, Ho-Tak, Golkowski, Martin G., Ong, Shao-En, Beavo, Joseph A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544305/
https://ncbi.nlm.nih.gov/pubmed/28634298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703939114
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