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SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP

Luteinizing hormone (LH) stimulates steroidogenesis largely through a surge in cyclic AMP (cAMP). Steroidogenic rates are also critically dependent on the availability of cholesterol at mitochondrial sites of synthesis. This cholesterol is provided by cellular uptake of lipoproteins, mobilization of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shimizu-Albergine, Masami, Van Yserloo, Brian, Golkowski, Martin G., Ong, Shao-En, Beavo, Joseph A., Bornfeldt, Karin E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035853/
https://ncbi.nlm.nih.gov/pubmed/27601673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611424113
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