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Analyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells

Specific functions for different cyclic nucleotide phosphodiesterases (PDEs) have not yet been identified in most cell types. Conventional approaches to study PDE function typically rely on measurements of global cAMP, general increases in cAMP-dependent protein kinase (PKA), or the activity of exch...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Beltejar, Michael-Claude G., Lau, Ho-Tak, Golkowski, Martin G., Ong, Shao-En, Beavo, Joseph A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5544305/
https://ncbi.nlm.nih.gov/pubmed/28634298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1703939114
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