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SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP

Luteinizing hormone (LH) stimulates steroidogenesis largely through a surge in cyclic AMP (cAMP). Steroidogenic rates are also critically dependent on the availability of cholesterol at mitochondrial sites of synthesis. This cholesterol is provided by cellular uptake of lipoproteins, mobilization of...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Shimizu-Albergine, Masami, Van Yserloo, Brian, Golkowski, Martin G., Ong, Shao-En, Beavo, Joseph A., Bornfeldt, Karin E.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5035853/
https://ncbi.nlm.nih.gov/pubmed/27601673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611424113
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