The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein.

Ítems similars

• In vitro mutagenesis of the v-sis transforming gene defines functional domains of its growth factor-related product.
  per: King, C R, et al.
  Publicat: (1985)
• A small v-sis/platelet-derived growth factor (PDGF) B-protein domain in which subtle conformational changes abrogate PDGF receptor interaction and transforming activity.
  per: Giese, N, et al.
  Publicat: (1990)
• Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.
  per: Fleming, T P, et al.
  Publicat: (1989)
• The phenotypic characteristics of simian sarcoma virus-transformed human fibroblasts suggest that the v-sis gene product acts solely as a PDGF receptor agonist in cell transformation.
  per: Johnsson, A, et al.
  Publicat: (1986)
• Membrane-anchored form of v-sis/PDGF-B induces mitogenesis without detectable PDGF receptor autophosphorylation
  Publicat: (1991)