Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.

v-sis represents a prototype for the class of oncogenes that encode growth factors. Whether its platelet-derived growth factor (PDGF)-like product functionally activates its receptors within the cell or at the cell surface has potential implications in efforts to intervene with the v-sis-transformed...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Fleming, T P, Matsui, T, Molloy, C J, Robbins, K C, Aaronson, S A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298215/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2813378/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.20.8063
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