Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.

Eitemau Tebyg

• The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein.
  gan: Robbins, K C, et al.
  Cyhoeddwyd: (1985)
• In vitro mutagenesis of the v-sis transforming gene defines functional domains of its growth factor-related product.
  gan: King, C R, et al.
  Cyhoeddwyd: (1985)
• Autocrine stimulation by the v-sis gene product requires a ligand- receptor interaction at the cell surface
  Cyhoeddwyd: (1988)
• A small v-sis/platelet-derived growth factor (PDGF) B-protein domain in which subtle conformational changes abrogate PDGF receptor interaction and transforming activity.
  gan: Giese, N, et al.
  Cyhoeddwyd: (1990)
• Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit.
  gan: Rao, C D, et al.
  Cyhoeddwyd: (1986)