A small v-sis/platelet-derived growth factor (PDGF) B-protein domain in which subtle conformational changes abrogate PDGF receptor interaction and transforming activity.

Deletion scanning mutagenesis within the transforming region of the v-sis oncogene was used to dissect structure-function relationships. Mutations affecting codons within a domain encoding amino acids 136 through 148 had no effect upon homodimer formation or recognition by antisera which detect dete...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Biol
Prif Awduron: Giese, N, LaRochelle, W J, May-Siroff, M, Robbins, K C, Aaronson, S A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 1990
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361263/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1697931/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.10.5496
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg