A small v-sis/platelet-derived growth factor (PDGF) B-protein domain in which subtle conformational changes abrogate PDGF receptor interaction and transforming activity.

Deletion scanning mutagenesis within the transforming region of the v-sis oncogene was used to dissect structure-function relationships. Mutations affecting codons within a domain encoding amino acids 136 through 148 had no effect upon homodimer formation or recognition by antisera which detect dete...

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Библиографические подробности
Опубликовано в: :Mol Cell Biol
Главные авторы: Giese, N, LaRochelle, W J, May-Siroff, M, Robbins, K C, Aaronson, S A
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 1990
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC361263/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1697931/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.10.5496
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