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Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis
The uridyl transferases TUT4 and TUT7 switch between two modes of activity that either promotes let-7 expression (monoU) or marks it for degradation (oligoU). Lin28 modulates the switch via recruitment of TUT4(7) to pre-let-7 in stem cells and human cancers. We found TUT4(7) utilize two multi-domain...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5542866/ https://ncbi.nlm.nih.gov/pubmed/28671666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3428 |
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