Uridylation by TUT4 and TUT7 Marks mRNA for Degradation

Uridylation occurs pervasively on mRNAs, yet its mechanism and significance remain unknown. By applying TAIL-seq, we identify TUT4 and TUT7 (TUT4/7), also known as ZCCHC11 and ZCCHC6, respectively, as mRNA uridylation enzymes. Uridylation readily occurs on deadenylated mRNAs in cells. Consistently,...

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Bibliografske podrobnosti
izdano v:Cell
Main Authors: Lim, Jaechul, Ha, Minju, Chang, Hyeshik, Kwon, S. Chul, Simanshu, Dhirendra K., Patel, Dinshaw J., Kim, V. Narry
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720960/
https://ncbi.nlm.nih.gov/pubmed/25480299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.10.055
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