A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7

The LIN28:pre-let-7:TUTase ternary complex regulates pluripotency and oncogenesis by controlling processing of the let-7 family of microRNAs. The complex oligouridylates the 3′ ends of pre-let-7 molecules, leading to their degradation via the DIS3L2 exonuclease. Previous studies suggest that compone...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yu, Chunxiao, Wang, Longfei, Rowe, R. Grant, Han, Areum, Ji, Wanying, McMahon, Conor, Baier, Alexander S., Huang, Yu-Chung, Marion, William, Pearson, Daniel S., Kruse, Andrew C., Daley, George Q., Wu, Hao, Sliz, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060709/
https://ncbi.nlm.nih.gov/pubmed/32060122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919409117
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