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Mechanism of Dis3L2 substrate recognition in the Lin28/let-7 pathway
The pluripotency factor Lin28 inhibits the biogenesis of the let-7 family of mammalian microRNAs(1–4). Lin28 is highly expressed in embryonic stem cells and has a fundamental role in regulation of development(5), glucose metabolism(6) and tissue regeneration(7). Alternatively, Lin28 overexpression i...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4192074/ https://ncbi.nlm.nih.gov/pubmed/25119025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13553 |
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