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A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway
The pluripotency factor Lin28 blocks the expression of let-7 microRNAs (miRNAs) in undifferentiated cells during development and functions as an oncogene in a subset of cancers(1). Lin28 binds to let-7 precursor RNAs and recruits 3′ terminal uridylyl transferases (TUTases) to selectively inhibit let...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651781/ https://ncbi.nlm.nih.gov/pubmed/23594738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12119 |
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