The LIN28/let-7 Pathway in Cancer

Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B, two highly related RNA binding proteins (RBPs) and proto-oncogenes, is responsible for the global post-transcriptional...

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Dades bibliogràfiques
Publicat a:Front Genet
Autors principals: Balzeau, Julien, Menezes, Miriam R., Cao, Siyu, Hagan, John P.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2017
Matèries:
Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368188/
https://ncbi.nlm.nih.gov/pubmed/28400788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2017.00031
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