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Presenilin-dependent γ-secretase activity modulates thymocyte development
In neuronal cells, presenilin-dependent γ-secretase activity cleaves amyloid precursor proteins to release Aβ peptides, and also catalyzes the release of the intracellular domain of the transmembrane receptor Notch. Accumulation of aberrant Aβ peptides appears to be causally related to Alzheimer...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC55417/ https://ncbi.nlm.nih.gov/pubmed/11470902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.161102498 |
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