Presenilin-dependent γ-secretase activity modulates thymocyte development
In neuronal cells, presenilin-dependent γ-secretase activity cleaves amyloid precursor proteins to release Aβ peptides, and also catalyzes the release of the intracellular domain of the transmembrane receptor Notch. Accumulation of aberrant Aβ peptides appears to be causally related to Alzheimer's d...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55417/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11470902/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.161102498 |
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