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Moonlighting activity of presenilin in plants is independent of γ-secretase and evolutionarily conserved
Presenilins (PS) provide the catalytic activity for γ-secretase, which cleaves physiologically relevant substrates including Notch, ErbB4, and APP. Recent genetic studies indicated that the contribution of PS1 to mouse development includes γ-secretase-independent functions that cannot be easily expl...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948938/ https://ncbi.nlm.nih.gov/pubmed/17684101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702038104 |
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