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Moonlighting activity of presenilin in plants is independent of γ-secretase and evolutionarily conserved

Presenilins (PS) provide the catalytic activity for γ-secretase, which cleaves physiologically relevant substrates including Notch, ErbB4, and APP. Recent genetic studies indicated that the contribution of PS1 to mouse development includes γ-secretase-independent functions that cannot be easily expl...

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Detalhes bibliográficos
Main Authors: Khandelwal, Abha, Chandu, Dilip, Roe, Catherine M., Kopan, Raphael, Quatrano, Ralph S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948938/
https://ncbi.nlm.nih.gov/pubmed/17684101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702038104
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