Presenilin Regulates Insulin Signaling via a γ-Secretase-independent Mechanism

Presenilin (PS), a causative molecule of familial Alzheimer disease, acts as a crucial component of the γ-secretase complex, which is required to cleave type I transmembrane proteins such as amyloid precursor protein and Notch. However, it also functions through γ-secretase-independent pathways. Rec...

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Bibliographic Details
Main Authors: Maesako, Masato, Uemura, Kengo, Kuzuya, Akira, Sasaki, Kazuki, Asada, Megumi, Watanabe, Kiwamu, Ando, Koichi, Kubota, Masakazu, Kihara, Takeshi, Kinoshita, Ayae
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3137102/
https://ncbi.nlm.nih.gov/pubmed/21622565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.248922
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