N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production

Sequential processing of amyloid precursor protein (APP) by β- and γ-secretase leads to the generation of amyloid-β (Aβ) peptides, which plays a central role in Alzheimer's disease pathogenesis. APP is capable of forming a homodimer through its extracellular domain as well as transmembrane GXXX...

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Bibliographische Detailangaben
Hauptverfasser: Asada-Utsugi, Megumi, Uemura, Kengo, Noda, Yasuha, Kuzuya, Akira, Maesako, Masato, Ando, Koichi, Kubato, Masakazu, Watanabe, Kiwamu, Takahashi, Makio, Kihara, Takeshi, Shimohama, Shun, Takahashi, Ryosuke, Berezovska, Oksana, Kinoshita, Ayae
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395082/
https://ncbi.nlm.nih.gov/pubmed/21699541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07364.x
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