Nalaganje...

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation

Obesity and type 2 diabetes are risk factors of Alzheimer’s disease (AD). We reported that a high fat diet (HFD) promotes amyloid precursor protein (APP) cleavage by β-site APP cleaving enzyme 1 (BACE1) without increasing BACE1 levels in APP transgenic mice. However, the detailed mechanism had remai...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Maesako, Masato, Uemura, Maiko, Tashiro, Yoshitaka, Sasaki, Kazuki, Watanabe, Kiwamu, Noda, Yasuha, Ueda, Karin, Asada-Utsugi, Megumi, Kubota, Masakazu, Okawa, Katsuya, Ihara, Masafumi, Shimohama, Shun, Uemura, Kengo, Kinoshita, Ayae
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587376/
https://ncbi.nlm.nih.gov/pubmed/26414661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131199
Oznake: Označite
Brez oznak, prvi označite!