High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation

Obesity and type 2 diabetes are risk factors of Alzheimer’s disease (AD). We reported that a high fat diet (HFD) promotes amyloid precursor protein (APP) cleavage by β-site APP cleaving enzyme 1 (BACE1) without increasing BACE1 levels in APP transgenic mice. However, the detailed mechanism had remai...

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Publicat a:PLoS One
Autors principals: Maesako, Masato, Uemura, Maiko, Tashiro, Yoshitaka, Sasaki, Kazuki, Watanabe, Kiwamu, Noda, Yasuha, Ueda, Karin, Asada-Utsugi, Megumi, Kubota, Masakazu, Okawa, Katsuya, Ihara, Masafumi, Shimohama, Shun, Uemura, Kengo, Kinoshita, Ayae
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587376/
https://ncbi.nlm.nih.gov/pubmed/26414661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131199
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