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Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody

Exposure of susceptible neuroblastoma N2a cells to mouse scrapie prions leads to infection, as evidenced by the continued presence of the scrapie form of the prion protein (PrP(Sc)) and infectivity after 300 or more cell doublings. We find that exposure to phosphatidylinositol-specific phospholipase...

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Autores principales: Enari, Masato, Flechsig, Eckhard, Weissmann, Charles
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2001
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC55414/
https://ncbi.nlm.nih.gov/pubmed/11470893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.151242598
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