B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice

Prion replication in spleen and neuroinvasion after i.p. inoculation of mice is impaired in forms of immunodeficiency where mature B lymphocytes are lacking. In spleens of wild-type mice, infectivity is associated with B and T lymphocytes and stroma but not with circulating lymphocytes. We generated...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Montrasio, Fabio, Cozzio, Antonio, Flechsig, Eckhard, Rossi, Daniela, Klein, Michael A., Rülicke, Thomas, Raeber, Alex J., Vosshenrich, Christian A. J., Proft, Juliane, Aguzzi, Adriano, Weissmann, Charles
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 2001
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC31174/
https://ncbi.nlm.nih.gov/pubmed/11274428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051609398
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