B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice

Prion replication in spleen and neuroinvasion after i.p. inoculation of mice is impaired in forms of immunodeficiency where mature B lymphocytes are lacking. In spleens of wild-type mice, infectivity is associated with B and T lymphocytes and stroma but not with circulating lymphocytes. We generated...

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Detalhes bibliográficos
Main Authors: Montrasio, Fabio, Cozzio, Antonio, Flechsig, Eckhard, Rossi, Daniela, Klein, Michael A., Rülicke, Thomas, Raeber, Alex J., Vosshenrich, Christian A. J., Proft, Juliane, Aguzzi, Adriano, Weissmann, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC31174/
https://ncbi.nlm.nih.gov/pubmed/11274428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051609398
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