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Antibody to DNA detects scrapie but not normal prion protein
Prion diseases, a group of fatal neurodegenerative disorders, are characterized by the presence of the abnormal scrapie isoform of prion protein (PrP(Sc)) in affected brains. A conformational change is believed to convert the normal cellular prion protein into PrP(Sc). Detection of PrP(Sc) for diagn...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC337061/ https://ncbi.nlm.nih.gov/pubmed/14734804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307825100 |
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