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The role of glycophospatidylinositol anchor in the amplification of the scrapie isoform of prion protein in vitro

Transmissible spongiform encephalopathies are associated with an autocatalytic conversion of normal prion protein, PrP(C), to a protease-resistant form, PrPres. This autocatalytic reaction can be reproduced in vitro using a procedure called protein misfolding cyclic amplification (PMCA). Here we sho...

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Bibliografiska uppgifter
Huvudupphovsmän: Kim, Jae-Il, Surewicz, Krystyna, Gambetti, Pierluigi, Surewicz, Witold K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856614/
https://ncbi.nlm.nih.gov/pubmed/19854187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.10.049
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