Mammalian Prions Generated from Bacterially Expressed Prion Protein in the Absence of Any Mammalian Cofactors

Transmissible spongiform encephalopathies (TSEs) are a group of neurodegenerative diseases that are associated with the conformational conversion of a normal prion protein, PrP(C), to a misfolded aggregated form, PrP(Sc). The protein-only hypothesis asserts that PrP(Sc) itself represents the infecti...

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Bibliographic Details
Main Authors: Kim, Jae-Il, Cali, Ignazio, Surewicz, Krystyna, Kong, Qingzhong, Raymond, Gregory J., Atarashi, Ryuichiro, Race, Brent, Qing, Liuting, Gambetti, Pierluigi, Caughey, Byron, Surewicz, Witold K.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863186/
https://ncbi.nlm.nih.gov/pubmed/20304915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.113464
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